See Also: hypoxanthine-guanine phosphoribosyl tranferase marker(medicine)
hypoxanthine-guanine phosphoribosyl transferase(medicine)
hypoxanthine guanine phosphoribosyltransferase(medicine)
hypoxanthine-guanine-xanthine phosphoribosyltransferase(medicine)
hypoxanthine guanine phosphoribosyltransferase deficiency(medicine)
phosphoribosyl pyrophosphate(medicine)
N-(5'-phosphoribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase(medicine)
Hypoxanthine(medicine)
hypoxanthine phosphoribosyltransferase(medicine)
hypoxanthine oxidase(medicine)

misbehave (iou) and hypoxanthine-guanine phosphoribosyl tranferase marker (medicine)


misbehave (iou)



misbehave verb intrans. & (now rare) refl. L15.
[from MIS-1 1 + BEHAVE.]
Behave badly; conduct oneself improperly. L15.
M. Warnock Having misbehaved, I was shut in the night nursery as a punishment.
Of a machine etc.: fail to function correctly. M19.
misbehaviour noun L15.

hypoxanthine-guanine phosphoribosyl tranferase marker (medicine)


hypoxanthine-guanine phosphoribosyl tranferase marker


The gene which codes for the enzyme hypoxanthine-guanine phosphoribosyl transferase. It is a selectable marker because cells which have a defective version of this gene are resistant to poisoning by toxic purine Derivatives which result from the metabolic pathway that the HGPRT enzyme catalyses. (The purine Derivatives are toxic because they incorporate into DNA as a result of the HGPRT enzyme's actions). Because the defective gene cannot produce the enzyme, no toxic purine Derivatives are produced, the gene can therefore be selected for.