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Peptidyltransferase (medicine)


peptidyltransferase
<enzyme> An enzyme that catalyses the transfer of aminoacyl-tRNA to formyl-methionine-tRNA or peptidyl-tRNA during peptide chain elongation. It is a part of the 50 s (bacteria) and 60 s (eukaryotes) ribosomal subunits.

Integral enzymic activity of the large subunit of a ribosome, catalysing the formation of a peptide bond between the carboxy terminus of the nascent chain and the amino group of an arriving tRNA associated amino acid.

Chemical name: Peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase

Registry number: EC 2.3.2.12