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calpain (medicine)


calpain
<enzyme> Calcium activated cytoplasmic proteases containing the EF hand motif. Calpain I is activated by micromolar calcium, Calpain II by millimolar calcium.

Calpain has two subunits, the larger (80 kD) has 4 domains one homologous with papain, one with calmodulin, the smaller (30 kD) has one domain homologous with calmodulin. First isolated from erythrocytes, but now described from other cells.