See Also: Selye, Hans (Hugo Bruno)(encyclopedia)
Selye, Hans(medicine)
adaptation syndrome of Selye(medicine)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
Bettelheim, Bruno(encyclopedia)
Bruno, Giordano(encyclopedia)
Bloch, Bruno(medicine)
Fleischer, Bruno(medicine)
Walter, Bruno(encyclopedia)
Kisch, Bruno(medicine)

diacylglycerol (medicine) and Selye, Hans (Hugo Bruno) (sh)


diacylglycerol (medicine)


diacylglycerol
Glycerol substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction. Elevated levels of DAG in membranes activate protein kinase C by stabilising its catalytically active complex with membrane bound phosphatidyl serine and calcium.


Selye, Hans (Hugo Bruno) (sh)




born Jan. 26, 1907, Vienna, Austria-Hungary
died Oct. 16, 1982, Montreal, Que., Can.

Austrian-born Canadian endocrinologist.

In early work on the effects of stress, he injected ovarian hormones into rats; this stimulated the adrenal glands, causing deterioration of the thymus gland, ulcers, and finally death. He later showed that physical injury, environmental stress, and toxins could have similar effects. Extending his theory to humans, he proved that a stress-induced hormonal system breakdown could lead to so-called "diseases of adaptation," including heart disease and hypertension. He was president of the International Institute of Stress and wrote 33 books, including Stress Without Distress (1974).