See Also: globoid cell leukodystrophy(medicine)
leukodystrophy, globoid cell(medicine)
globoid cell(medicine)
globoid(dictionary)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
leukodystrophy(medicine)
metachromatic leukodystrophy(medicine)
leukodystrophy, metachromatic(medicine)
adrenal leukodystrophy(medicine)
leukodystrophy with diffuse Rosenthal fibre formation(medicine)

leukodystrophy, globoid cell (medicine)


leukodystrophy, globoid cell


An inherited metabolic disorder of the nervous system, particularly the white matter. It is characterised histologically by a paucity of myelin and oligodendroglia, severe astrocytic gliosis, and massive infiltration with unique multinucleated globoid cells which are enriched in galactosylceramide. The primary genetic defect is a deficiency of galactosylceramidase.