See Also: leukodystrophy, globoid cell(medicine)
globoid cell leukodystrophy(medicine)
Nicardipine hcl(health)
nicardipine(medicine)
globoid(dictionary)
globoid cell(medicine)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
leukodystrophy(medicine)
leukodystrophy, metachromatic(medicine)
metachromatic leukodystrophy(medicine)

leukodystrophy, globoid cell (medicine) and nicardipine (medicine)


leukodystrophy, globoid cell (medicine)


leukodystrophy, globoid cell


An inherited metabolic disorder of the nervous system, particularly the white matter. It is characterised histologically by a paucity of myelin and oligodendroglia, severe astrocytic gliosis, and massive infiltration with unique multinucleated globoid cells which are enriched in galactosylceramide. The primary genetic defect is a deficiency of galactosylceramidase.


nicardipine (medicine)


nicardipine
<chemical> 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) methyl 2-(methyl(phenylmethyl)amino)-3,5-pyridinecarboxylic acid ethyl ester. A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agent.

Pharmacological action: anti-asthmatic agents, antihypertensive agents, calcium channel blockers, vasodilator agents.

Chemical name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester