See Also: calmodulin-dependent protein kinase IV kinase(medicine)
Valdivia, Pedro de(encyclopedia)
AMP-activated protein kinase kinase(medicine)
MAPKAP kinase-2 reactivating kinase(medicine)
ribosomal protein S6 kinase kinase(medicine)
protein kinase B kinase(medicine)
leukocyte tyrosine kinase receptor tyrosine kinase(medicine)
MEK kinase(medicine)
p34 kinase(medicine)
RAP kinase(medicine)

map kinase kinase kinase (medicine) and Valdivia, Pedro de (sh)


map kinase kinase kinase (medicine)


MAP kinase kinase kinase
<enzyme> From pc12 cells; reactivates map kinase kinase inactivated by protein phosphatase 2a by phosphorylation of serine residues; tak1 (tgf-beta-activated kinase 1) is a member of the mapkkk family; genbank ab006787 (mouse)

Registry number: EC 2.7.10.-

Synonym: mapkkk, tak1 mapkkk, ask1 (kinase), apoptosis signal-regulating kinase 1


Valdivia, Pedro de (sh)




born งใ 1498, Extremadura, Spain
died January 1554, Tucapel, Viceroyalty of Peru

Spanish conquistador.

After serving with the Spanish army in Italy and Flanders, he was sent to South America in 1534, where he served under Francisco Pizarro in Peru. In 1540 he led an expedition of 150 Spaniards into Chile, where he defeated a large force of Indians and founded Santiago in 1541. He extended Spanish rule south to the Bio-Bio River in 1546, fought again in Peru (1546-48), and returned to Chile as governor in 1549. He began to conquer Chile south of the Bio-Bio and founded Concepcion in 1550. He was killed in a campaign against the Araucanian Indians.