See Also: thyrotoxic complement-fixation factor(medicine)
complement fixation(medicine)
complement fixation tests(medicine)
complement-fixation reaction(medicine)
complement-fixation test(medicine)
Complement factor I(medicine)
complement factor h(medicine)
complement 3 nephritic factor(medicine)
complement chemotactic factor(medicine)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)

thyrotoxic complement-fixation factor (medicine)


thyrotoxic complement-fixation factor


A form of thyrotoxin; an antigen found most readily in thyroid tissue from thyrotoxic individuals; known to be chemically and immunologically distinct from thyroglobulin, and fixes complement when combined with antibody related to the gamma-globulin fraction of serum. With the exception of extremely small concentrations, the antigen is rarely found in normal glands or in diseased glands that are not associated with thyrotoxicosis; it is probably an intracellular substance (possibly a constituent of the "microsomal fraction"), and does not contain iodine in significant quantity. Not related to the complement-fixation reaction occurring with serum in Hashimoto's disease, in which the antigen is thyroglobulin.